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NFL Week 12 injuries: Chiefs' Patrick Mahomes down three playmakers vs. Raiders; Justin Jefferson questionable

Breakdown of key player injuries for matchups like Saints vs. Falcons, Steelers vs. Bengals, and Jaguars vs. Texans.

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Notable players out, including CB Marshon Lattimore, RB Kendre Miller, and WR Mack Hollins. QB Taylor Heinicke questionable.

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Steelers' Minkah Fitzpatrick and Bengals' Joe Burrow among key players ruled out. Several others questionable.

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Jaguars' top corner Tyson Campbell out. Texans' WR Noah Brown and S Jimmie Ward won't play.

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Buccaneers face defensive challenges with key players like Lavonte David and Jamel Dean out. Colts have their own injury concerns.

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Patriots' Ja'Whaun Bentley, Trent Brown, and others questionable. Giants dealing with injuries to key players like OT Evan Neal and DT Dexter Lawrence.

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Panthers without TE Hayden Hurst and S Jeremy Chinn. Titans dealing with injuries to WR Treylon Burks and OT Chris Hubbard.

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Rams' S Quentin Lake out. Cardinals facing challenges with multiple players out or questionable.

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Browns' Denzel Ward and Marquise Goodwin out. Chiefs, Raiders, Bills, and Eagles also dealing with key injuries.

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